智鼠故事 
Gsdmd-KO 基因敲除小鼠
纯合子现货秒杀
复苏/繁育服务
产品名称
Gsdmd-KO 基因敲除小鼠
产品编号
S-KO-12963
品系全称
C57BL/6NCya-Gsdmdem1/Cya
品系背景
C57BL/6NCya
品系编号
KOCMP-69146-Gsdmd-B6N-VA
品系状态
使用本品系发表的文献需注明： Gsdmd-KO 基因敲除小鼠 mice (Strain S-KO-12963) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量
基因
基因全称
gasdermin D
基因别称
DF5L，M2-4，Dfna5l，GsdmD-1，Gsdmdc1，1810036L03Rik
染色体号
Chr 15 (Mouse)
NCBI ID
转录本 ID
NCBI: NM_026960 | Ensembl: ENSMUST00000023238
修饰方式
全身性基因敲除
靶向范围
Exon 2~11
敲除长度
~4.3 kb
品系说明
该品系是基于策略设计时的数据库信息制作而成，建议您在购买前查询最新的数据库和相关文献，以获取最准确的表型信息。
表型提示
MGI:1916396Mice homozygous for a knock-out allele are viable and grossly normal with no apparent defects in the development and maintenance of the intestinal epithelium. Mice homozygous for another null allele exhibit impaired induced pyroptosis and Il1b secretion.
发表文献
MedComm
2026-04-23
High‐Throughput Screening Reveals That CeeNU Acts as a New NLRP3 Inflammasome Inhibitor
eLife
2025-02-24
A VgrG2b fragment cleaved by caspase-11/4 promotes Pseudomonas aeruginosa infection through suppressing the NLRP3 inflammasome
Cellular & Molecular Immunology
2024-10-07
The TET3 inflammasome senses unique long HSV-1 proteins for virus particle budding from the nucleus
Cell Death Discovery
2024-06-20
CCL11 released by GSDMD-mediated macrophage pyroptosis regulates angiogenesis after hindlimb ischemia
Nature Cell Biology
2024-03-26
A palmitoylation–depalmitoylation relay spatiotemporally controls GSDMD activation in pyroptosis
Advanced Science
2024-02-27
Gasdermin-E-Dependent Non-Canonical Pyroptosis Promotes Drug-Induced Liver Failure by Promoting CPS1 deISGylation and Degradation
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发表文献
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