智鼠故事 
Nlrp3-KO 基因敲除小鼠
复苏/繁育服务
产品名称
Nlrp3-KO 基因敲除小鼠
产品编号
S-KO-05210
品系全称
C57BL/6NCya-Nlrp3em1/Cya
品系背景
C57BL/6NCya
品系编号
KOCMP-216799-Nlrp3-B6N-VA
品系状态
使用本品系发表的文献需注明： Nlrp3-KO 基因敲除小鼠 mice (Strain S-KO-05210) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量
基因
基因全称
NLR family, pyrin domain containing 3
基因别称
FCU，MWS，FCAS，Cias1，Mmig1，NALP3，Pypaf1，AII/AVP，AGTAVPRL
染色体号
Chr 11 (Mouse)
NCBI ID
转录本 ID
NCBI: NM_145827 | Ensembl: ENSMUST00000101148
修饰方式
全身性基因敲除
靶向范围
Exon 3~6
敲除长度
~9.1 kb
品系说明
该品系是基于策略设计时的数据库信息制作而成，建议您在购买前查询最新的数据库和相关文献，以获取最准确的表型信息。
表型提示
MGI:2653833Mice homozygous for null mutations exhibit attenuated inflammatory responses related to decrease secretion of IL-1beta and IL-18. Mice heterozygous for activating mutations suffer from autoinflammatory attacks that lead to organ failure and death before weaning.
发表文献
Advanced Science
2026-02-27
Sirt3 Genetically Engineered Apoptotic Bodies Alleviate Skeletal Aging by Limiting Aggravated NLRP3 Inflammasome Activation of Senescent Macrophages
Nature Communications
2026-02-05
Microbiota-derived IPA protects against colitis by regulating intestinal HMGCS2-mediated ketogenesis to facilitate mucosal healing
Signal Transduction and Targeted Therapy
2025-09-23
Ninjurin-1 mediates cell lysis and detrimental inflammation of PANoptosis during influenza A virus infection
Science Advances
2025-04-25
The P2X7R/NLRP3 inflammasome axis suppresses enthesis regeneration through inflammatory and metabolic macrophage-stem cell cross-talk
Cellular & Molecular Immunology
2024-10-07
The TET3 inflammasome senses unique long HSV-1 proteins for virus particle budding from the nucleus
Cellular & Molecular Immunology
2023-11-26
Integrated NLRP3, AIM2, NLRC4, Pyrin inflammasome activation and assembly drive PANoptosis
1
2
发表文献
点击查看发表文献 >>
