智鼠故事 
Nr4a1-KO 基因敲除小鼠
复苏/繁育服务
产品名称
Nr4a1-KO 基因敲除小鼠
产品编号
S-KO-02468
品系全称
C57BL/6NCya-Nr4a1em1/Cya
品系背景
C57BL/6NCya
品系编号
KOCMP-15370-Nr4a1-B6N-VA
品系状态
使用本品系发表的文献需注明： Nr4a1-KO 基因敲除小鼠 mice (Strain S-KO-02468) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量
基因
基因全称
nuclear receptor subfamily 4, group A, member 1
基因别称
Hmr，N10，TR3，Gfrp，Hbr1，NP10，TIS1，GFRP1，Hbr-1，NGFIB，nur77，NGFI-B，NUR77-1，NUR77-2
染色体号
Chr 15 (Mouse)
NCBI ID
转录本 ID
NCBI: NM_010444 | Ensembl: ENSMUST00000023779
修饰方式
全身性基因敲除
靶向范围
Exon 3~6
敲除长度
~1.5 kb
品系说明
该品系是基于策略设计时的数据库信息制作而成，建议您在购买前查询最新的数据库和相关文献，以获取最准确的表型信息。
表型提示
MGI:1352454Mice homozygous for a targeted null mutation are viable, fertile, and display a normal HPA axis function, as well as normal thymic and peripheral T cell deletion. Homozygous KO decreases apoptosis and increases proliferation of B cell stimulated by a single antigen.
发表文献
iScience
2026-01-28
Estrogen upregulates NR4A1 to counter TGF beta induced pulmonary fibrosis therapeutic insights for IPF
Advanced Science
2025-11-20
CD27 and ICOS as Targets of PD‐1/PD‐L1 Signaling to Regulate Resident Memory CD8+ T‐Cell‐Mediated Pulmonary Protection and Pathology
Immunity
2023-03
The orphan receptor Nur77 binds cytoplasmic LPS to activate the non-canonical NLRP3 inflammasome
Cell Death Discovery
2021-06-03
NR4A1 enhances MKP7 expression to diminish JNK activation induced by ROS or ER-stress in pancreatic β cells for surviving
FASEB J.
2020-09-20
GPA peptide enhances Nur77 expression in intestinal epithelial cells to exert a protective effect against DSS-induced colitis
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